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ea0092op-12-05 | Oral Session 12: Emerging Insights into Thyroid Cancer Genetics | ETA2023

Braf fusion genes in a large cohort of thyroid carcinomas

Bulanova Barbora , Sykorova Vlasta , Mastnikova Karolina , Vaclavikova Eliska , Moravcova Jitka , Vlcek Petr , Lastuvka Petr , Katra Rami , Bavor Petr , Novakova Kodetova Daniela , Chovanec Martin , Drozenova Jana , Astl Jaromir , Hrabal Petr , Vcelak Josef , Bendlova Bela

Objectives: Effective patient management is about finding a balance between overtreatment and undertreatment. Finding the border is very difficult due to the hardly predictable development of carcinoma. Molecular markers and their testing could help distinguish between low-grade and high- grade carcinomas. One of these molecular markers is a BRAF fusion gene. The aim of this study was to identify BRAF fusion genes in thyroid carcinomas, to correlate them with...

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ea0092ps1-08-09 | Translational 1 | ETA2023

Identification of rare braf variants in thyroid nodules

Kuklikova Vlasta , Bulanova Barbora , Vaclavikova Eliska , Moravcova Jitka , Mastnikova Karolina , Vlcek Petr , Katra Rami , Novakova Kodetova Daniela , Lastuvka Petr , Bavor Petr , Drozenova Jana , Chovanec Martin , Vcelak Josef , Bendlova Bela

Objectives: The substitution BRAF p.V600E is the most common genetic cause of the papillary thyroid carcinoma (PTC) and represents more than 95% genetic variants in BRAF gene. Other rare variants in the BRAF gene include other substitutions (e.g. p.K601E), small deletions or insertions close to codon 600. The aim of this study was to analyze a large cohort of thyroid nodules for rare genetic variants in the BRAF gene.M...

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Endocrine Abstracts

Braf fusion genes in a large cohort of thyroid carcinomas

Identification of rare braf variants in thyroid nodules

BiosciAbstracts